The W223 Mercedes-Maybach S-Class was revealed on 19 November 2020 with model designations S 580 4MATIC and S 680 4MATIC.The Mercedes-Maybach is 18 centimetres longer than the predecessor. Several design cues, separating the Mercedes-Maybach from Mercedes-Benz, are carried over. Another first for Mercedes-Benz is the frontal airbags for the rear passengers.

Available engines are a 4.0-litre biturbo V8 for the S 580 4MATIC and a 6.0-litre biturbo V12 for the S 680 4MATIC. Both are fitted with standard 4MATIC all-wheel-drive system. The rear-wheel-steering system for reducing the turning radius is optional extra cost. The turning angle can be set at 4.5° or 10°, reducing the turning radius from 13.1 metres (43 ft) to 12.2 metres (40 ft) and 11.2 metres (37 ft) respectively.A third engine option is the 3.0-litre petrol inline six-cylinder engine with E-Boost. Called the S 480 4MATIC, it was developed for the Chinese market due to the high displacement tax imposed in that country and is not sold anywhere else.

In Germany Mercedes-Maybach announced the launch date of May 2021 for ordering and the delivery date of July 2021.

Mercedes-Benz launched the S 580 and the S 680 in India on 3 March 2022. The S 580 is assembled at Mercedes-Benz's plant in Chakan, Pune.